Effect of Hypoxia on the Induction of Premature Cellular Senescence in the Cells of Periodontium during Orthodontic Tooth Loading
Luay Thanoon Younis *
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Sungai Buloh, Malaysia.
Faisal Ismail Elsayed Bahnasi
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Sungai Buloh, Malaysia.
Aida Nur Ashikin Abd Rahman
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Sungai Buloh, Malaysia.
Mohamed Ibrahim Abu Hassan
Faculty of Dentistry, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Sungai Buloh, Malaysia.
*Author to whom correspondence should be addressed.
Abstract
During orthodontic treatment, application of forces to move the teeth within the dento-alveolar complex is associated with structural and biological tissues changes. One of the main changes is hypoxia which is due to the compression of blood vessels resulting in insufficient oxygenation of the tissues. On orthodontic loading, hypoxia causes irreversible cell cycle arrest (or so called cellular senescence) and apoptosis of the tissue cells around the teeth especially on the compression zone. Excessive hypoxia, in turn leads to a massive, an inevitable and detrimental destruction of tissues supporting the tooth such as remarkable root resorption. This mini-review is highlighting the effect of orthodontic force in inducing a local hypoxic environment and its consequences in causing cells death of the periodontal cells.
Keywords: Periodontal ligament, hypoxia, cellular senescence, tooth movement