Croton zambesicus Root Extract Exert Laxative Effect in Rats
Jude E. Okokon *
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
Augustine I. L. Bassey
Department of Pharmacology and Therapeutics, Faculty of Clinical Sciences, University of Uyo, Uyo, Nigeria.
Emmanuel E. Nyong
Department of Pharmacognosy and Natural Medicine, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
Utibe A. Edem
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: Croton zambesicus Muell Arg. (Euphorbiaceace) is a medicinal plant used traditionally in the treatment of some ailments.
Aim: The root extract of Croton zambesicus was evaluated for effect on the gastrointestinal tract (GIT).
Materials and Methods: The root extract of C. zambesicus (27-81 mg/kg) was investigated for laxative effect in rats using different experimental models to study its effect on the GIT.
Results: The extract was found to significantly increase the frequency and output of faecal matters in rats in all the experimental models studied.
Conclusion: The findings of this study show that the root extract of C. zambesicus has a significant laxative effect and this supports its use in ethnomedicine for the treatment of gastrointestinal tract disorders.
Keywords: Croton zambesicus, Purgative, GIT.