https://www.journalajob.com/index.php/AJOB/issue/feed 2026-07-15T07:50:29+00:00 Asian Journal of Biology [email protected] Open Journal Systems <p style="text-align: justify;">The aim of <strong>Asian Journal of Biology (ISSN: 2456-7124)</strong> is to publish high quality papers (<a href="https://journalajob.com/index.php/AJOB/general-guideline-for-authors">Click here for Types of paper</a>) with broad areas of Aerobiology, Agriculture, Anatomy, Astrobiology, Biochemistry, Bioengineering, Bioinformatics, Biomathematics or Mathematical Biology, Biomechanics, Biomedical research, Biophysics, Biotechnology, Building biology, Botany, Cell biology, Conservation Biology, Cryobiology, Developmental biology, Food biology, Ecology, Embryology, Entomology, Environmental Biology, Epidemiology, Ethology, Evolutionary Biology, Genetics, Herpetology, Histology, Ichthyology, Integrative biology, Limnology, Mammalogy, Marine Biology, Microbiology, Molecular Biology, Mycology, Neurobiology, Oceanography, Oncology, Ornithology, Population biology, Population ecology, Population genetics, Paleontology, Pathobiology or pathology, Parasitology, Pharmacology, Physiology, Psychobiology, Sociobiology, Structural biology, Virology and Zoology. By not excluding papers based on novelty, this journal facilitates the research and wishes to publish papers as long as they are technically correct and scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled, OPEN peer-reviewed, open-access INTERNATIONAL journal.</p> <p style="text-align: justify;"><strong>NAAS Score: 4.52 (2026) </strong></p> https://www.journalajob.com/index.php/AJOB/article/view/672 2026-07-15T07:50:29+00:00 KOUAME Yao Yves [email protected] KOUAKOU Yeboué Koffi François GOGAHY Konan KONAN Pulchérie Marie Chantal YAPI Houphouët Félix

<p><strong>Introduction:</strong> Malaria remains endemic in Côte d’Ivoire, and <em>Plasmodium falciparum</em> is the predominant species associated with malaria attacks.</p> <p><strong>Aims</strong>: This study evaluated the phytochemical composition, haemolytic effect, and antiplasmodial activity of an aqueous extract of <em>Cassia sieberiana</em> root bark against <em>P. falciparum</em> isolates.</p> <p><strong>Methods:</strong> The aqueous extract was prepared by decoction, and selected secondary metabolites were identified using colorimetric methods. Haemolytic activity was assessed using uninfected O+ red blood cells, with phosphate-buffered saline and Triton X-100 serving as the negative and positive controls, respectively. Antiplasmodial activity was evaluated against 30 <em>P. falciparum</em> isolates, with quinine used as the reference antimalarial molecule.</p> <p><strong>Results:</strong> The extract contained alkaloids, saponins, polyphenols, flavonoids, and catechic tannins, whereas gallic tannins, sterols and terpenes, and quinones were not detected. The measured haemolysis percentage was 0.619%. Antiplasmodial activity increased across the tested concentrations. At the highest tested concentration, the minimum and maximum IC50 values were 1.11 ± 0.00 μg/mL and 4.33 ± 0.00 μg/mL, respectively.</p> <p><strong>Conclusion:</strong> Under the reported <em>in vitro</em> conditions, the aqueous root-bark extract showed low haemolytic activity and inhibited <em>P. falciparum</em> isolates. These findings provide preliminary evidence that water-extractable constituents of <em>C. sieberiana</em> root bark may contribute to the observed antiplasmodial activity. Further standardised studies are required to confirm the dose-response relationship, cytotoxicity, selectivity, active constituents, and possible mechanisms.</p>

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